| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1817 | |
| Phytochemical name or plant extracts | Terminalia belerica extract | |
| PMID | 24399255 | |
| Literature evidence | These results suggested that TBME is able to induce anticancer effects on both lung and breast cancer cell lines through the modulation of Bcl-2 family proteins. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Terminalia belerica | |
| Geographical availability | Assam, Bangladesh, Borneo, Cambodia, China South-Central, East Himalaya, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, Nepal, Pakistan, Sri Lanka, Sulawesi, Sumatera, Thailand, Vietnam | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Lung cancer | |
| Target gene or protein | Bax, Bcl-2 | |
| Gene or Protein evidence | mechanism of apoptosis induction was demonstrated using western blotting and Bax/Bcl-2 ratio in both types of the cells was found increased, which leads to the activation of caspase cascade along with the cleavage of PARP. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | These results suggested that TBME is able to induce anticancer effects on both lung and breast cancer cell lines through the modulation of Bcl-2 family proteins. | |
| Cell line/ mice model | A549, MCF-7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | 28004224 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:170982-1 | |
| Safety | TBME showed significant cytotoxicity to both A549 and MCF-7 cells, whereas, no cytotoxicity was found in non-malignant WI-38 cells. |