| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-521 | |
| Phytochemical name or plant extracts | Tephrosin | |
| PMID | 31814840 | |
| Literature evidence | Expression levels of ABCG2 and P-gp were not significantly downregulated by these flavonoids. | |
| IUPAC name | (1R,14R)-14-hydroxy-17,18-dimethoxy-7,7-dimethyl-2,8,21-trioxapentacyclo[12.8.0.03,12.04,9.015,20]docosa-3(12),4(9),5,10,15,17,19-heptaen-13-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Tephrosia uniflora | |
| Geographical availability | Algeria, Angola, Botswana, Burkina, Cameroon, Cape Verde, Chad, Djibouti, Egypt, Eritrea, Ethiopia, Ghana, Gulf of Guinea Is., Gulf States, India, Iran, Ivory Coast, Kenya, Mali, Mauritania, Mozambique, Namibia, Niger, Nigeria, Northern Provinces, Oman, Pakistan, Saudi Arabia, Senegal, Socotra, Somalia, Sudan, Tanzania, Yemen, Zimbabwe | |
| Plant parts | Stem | |
| Other cancers | Breast cancer, Stomach cancer | |
| Target gene or protein | ABCG2, P-gp | |
| Gene or Protein evidence | We analyzed the impact of candidone, tephrosin, and bavachinin, as chemosensitizer on cell cytotoxicity, P-gp and ABCG2 mRNA expression level on two multidrug resistant cells, ABCG2 overexpressing human epithelial breast cancer cell line (MCF7/MX) | |
| Target pathways | NA | |
| IC50 | IC10 - 38.8 ± 4.28 nM against MCF7/MX | |
| Potency | Overall, bavachinin, tephrosin, and candidone showed potency to sensitize MDR cells to daunorubicin and mitoxantrone and could be considered as attractive MDR modulators for cancer treatment. | |
| Cell line/ mice model | MCF-7/MX, EPG85.257RDB | |
| Additional information | Tephrosin can potentially act as a dual natural inhibitor for VPAC1 and EGFR revealed through docking studies Chemosensitization to mitoxantrone and daunorubicin treatments was respectively, achieved in MCF7/MX and EPG85.257RDB cells in response to IC10 of the compound, and displays cytotoxicity on the afoermentioned cell lines | |
| PubChem ID | 114909 | |
| Additional PMIDs | 30810849 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:520980-1 | |
| Safety | NA |