| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1119 | |
| Phytochemical name or plant extracts | Tectochrysin | |
| PMID | 15930306 | |
| Literature evidence | Whereas GF120918 strongly inhibited the ATPase activity of wild-type ABCG2, neither 6-prenylchrysin nor tectochrysin altered the activity. | |
| IUPAC name | 5-hydroxy-7-methoxy-2-phenylchromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Hedychium spicatum | |
| Geographical availability | Assam, China South-Central, East Himalaya, India, Myanmar, Nepal, Thailand, Tibet, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | ABCG2 | |
| Gene or Protein evidence | Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The present results showed that the hydrophobic flavone 6-prenylchrysin was a potent inhibitor, 15-fold more efficient than chrysin. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Tectochrysin can be a useful agent for the treatment of colon cancer cell growth as well as an adjuvant agent for chemo-resistant cancer cells growth. | |
| PubChem ID | 5281954 | |
| Additional PMIDs | 26123287 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:796894-1 | |
| Safety | NA |