| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-703 | |
| Phytochemical name or plant extracts | Taxifolin | |
| PMID | 26922854 | |
| Literature evidence | Quercetin showed significant cytotoxic activity against HepG2 and MCF-7 cell lines with IC50 values of 4.88 and 0.87 μg/mL, respectively. | |
| IUPAC name | (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Calligonum polygonoides | |
| Geographical availability | Gulf States, Iran, Iraq, Kuwait, Lebanon-Syria, Pakistan, Palestine, Saudi Arabia, Sinai, Transcaucasus, Turkey, Yemen | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Liver cancer | |
| Target gene or protein | SOS1, Grb2, CCL2 | |
| Gene or Protein evidence | The natural compound, taxifolin, suppressed signaling transduction of SOS1 by blocking the interaction between SOS1 and Grb2, suggesting a potential utility of this compound as a therapeutic agent for AA patients with breast cancer. Elevated expression of SOS1 also enhanced cancer stemness through upregulation of PTTG1 and promoted M2 polarization of macrophages by CCL2 in metastatic sites. | |
| Target pathways | NA | |
| IC50 | 15.9 µg/ml against MCF-7 | |
| Potency | Quercetin, quercetin-3-O-glucuronide and taxifolin exhibited the highest cytotoxic effect against MCF-7 cells. | |
| Cell line/ mice model | MCF-7, HepG2 | |
| Additional information | NA | |
| PubChem ID | 439533 | |
| Additional PMIDs | 33446575 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:693386-1 DrugBank Accession Number DB02224 | |
| Safety | NA |