| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-45 | |
| Phytochemical name or plant extracts | Taro-derived extracts (TEs) | |
| PMID | 34376983 | |
| Literature evidence | In novel findings, we now show that the ability of TE to inhibit metastasis relies on immune T-cell-dependent, but not B cell or Natural Killer (NK)-cell-dependent mechanisms. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Colocasia esculenta | |
| Geographical availability | Assam, Bangladesh, China South-Central, China Southeast, East Himalaya, India, Laos, Malaya, Myanmar, Nepal, Sumatera, Taiwan, Thailand | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Ovarian cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Likewise, tumor cell migration is inhibited by TE. Using 2 immune competent, syngeneic models of TNBC, we confirm our earlier findings that tumor metastasis is potently inhibited by TE. We also demonstrate, for the first time, that TE directly inhibits breast cancer stem cells. | |
| Cell line/ mice model | Syngeneic Balb/c female mice, MDA-MD-231, MDA-MB-468, T47D, NCI-ADR RES-luc, OVCAR-3-luc | |
| Additional information | Administration of TE to mice elicits expansion of several spleen cell populations but it was not known if host immune cells contribute to the mechanism by which TE inhibits tumor cell dissemination. In novel findings, we now show that the ability of TE to inhibit metastasis relies on immune T-cell-dependent, but not B cell or Natural Killer (NK)-cell-dependent mechanisms. Thus, both tumor cell-autonomous and host immune factors contribute to the mechanisms underlying TE efficacy. A water-soluble extract of raw Taro (TE) potently inhibited breast tumor metastasis in 2 preclinical models of TNBC. A liposomal nanoparticle containing the taro-derived protein, designated taro lectin, inhibited proliferation of MDA-MD-231 cells as well as human glioblastoma U87 MG cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1170772-2 | |
| Safety | NA |