| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1897 | |
| Phytochemical name or plant extracts | Tanshinones | |
| PMID | 28459519 | |
| Literature evidence | CONCLUSION: We successfully introduced a two-step counter-current chromatography method to extract diterpenoid tanshinone, and demonstrated its antitumor activity. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Radix Salviae Miltiorrhizae | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Lung cancer, Liver cancer, Colon cancer, Stomach cancer, Myeloma | |
| Target gene or protein | Caspase3, Caspase 9, ATF-4 , PARP, p-eIF2 α, P-JNK, Caspase 12 | |
| Gene or Protein evidence | The Western blot showed that the expression of caspase3/9 protein and ATF-4 protein decreased gradually. However, the PARP, cleaved-caspase 3/9 and the expression of p-eIF2 α, P-JNK, and caspase- 12 increased gradually, in a dose-dependent fashion. | |
| Target pathways | NA | |
| IC50 | 4.4±0.5 μg/mL against MCF-7 | |
| Potency | Diterpenoid tanshinone inhibited the nine human tumor cell lines, with an IC50 of 4.37-29 μg/mL, with the PC9 and MCF-7 displaying the lowest values. | |
| Cell line/ mice model | MCF-7, A549, MKN-45, HGC-27, PC9, QGY-7703, HCT116, U266/ RPMI8226 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | 21073172 29238474 31316608 30174047 | |
| Additional sources of information | NA | |
| Safety | Fluorescence staining showed a lethal effect of diterpenoid tanshinone on PC9 cells. |