| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-405 | |
| Phytochemical name or plant extracts | Tanshinone IIA | |
| PMID | 20494511 | |
| Literature evidence | Mechanistic studies showed that ATA could induce significant reactive oxygen species (ROS) generation, Bax translocation to mitochondria, resulting in mitochondria damage, cytochrome c release, caspase-3 activation and apoptotic cell death. | |
| IUPAC name | 14,16-epoxy-20-nor-5(10),6,8,13,15-abietapentaene-11,12-dione | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Salvia miltiorrhiza | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Vietnam | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Prostate cancer | |
| Target gene or protein | LC3-II | |
| Gene or Protein evidence | Furthermore, Tan IIA could induce autophagy via LC3-II activation in various cancer cells such as prostate (PC-3), multiple myeloma (U266), lung (NCI-H460), and breast (MDA-MB-231) cells. | |
| Target pathways | Intrinsic apoptotic pathway | |
| IC50 | 2 μM against MDA-MB-468 | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-468, PC9, MCF-7, SKBR-3 | |
| Additional information | Inhibition of phosphoinositide 3-kinase/AKT pathway in prostate cancer | |
| PubChem ID | 164676 | |
| Additional PMIDs | 18698495 19429433 31316608 21048307 32048269 23813779 26018796 18788070 15849732 19885617 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:456707-1 | |
| Safety | NA |