| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1109 | |
| Phytochemical name or plant extracts | Tannic acid | |
| PMID | 28877394 | |
| Literature evidence | Tannic acid (TA) is a naturally occurring polyphenol that cross-links collagen type I and possesses anticancer potential. | |
| IUPAC name | [2,3-dihydroxy-5-[[(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]oxan-2-yl]methoxycarbonyl]phenyl] 3,4,5-trihydroxybenzoate | |
| Phytochemicals’ class or type of plant extracts | Polyphenol | |
| Source of phytochemicals or plant Extracts | Forsythia suspensa | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Inner Mongolia | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | CXCL12, CXCR4 | |
| Gene or Protein evidence | Tannic acid is an inhibitor of CXCL12 (SDF-1alpha)/CXCR4 with antiangiogenic activity. | |
| Target pathways | Wnt/β-catenin signaling pathway | |
| IC50 | NA | |
| Potency | Tannic acid (TA) is a naturally occurring polyphenol that cross-links collagen type I and possesses anticancer potential. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | The negative regulatory sequence ACTG and the tannic acid-sensitive 13-bp element in this region were shown to be responsible for the formation of the DNA-protein complex by electrophoretic mobility shift analysis and footprint analyses. | |
| PubChem ID | 16129778 | |
| Additional PMIDs | 24369505 9575208 21104029 31979292 12912963 28877394 26935808 26399961 28808404 12127233 24358166 34854406 34556209 28004224 25750276 34737014 31263506 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:608900-1 | |
| Safety | NA |