| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1709 | |
| Phytochemical name or plant extracts | Tangeretin | |
| PMID | 32146686 | |
| Literature evidence | While flavonoids have been studied extensively for estrogen receptor activity, they have not been well studied for their ability to modify progesterone receptor (PR) and glucocorticoid receptor (GR) signaling. | |
| IUPAC name | 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Citrus tankan | |
| Geographical availability | Albania, Argentina Northeast, Assam, Bangladesh, Borneo, China Southeast, Costa Rica, Cuba, Dominican Republic, Ecuador, El Salvador, Gambia, Guinea-Bissau, Haiti, Honduras, India, Jamaica, Japan, Korea, Mauritius, Mexico Southeast, Myanmar, Nansei-shoto, Pakistan, Panamá, Philippines, Puerto Rico, Réunion, Sri Lanka, Tadzhikistan, Taiwan, Vanuatu, Venezuela, Vietnam | |
| Plant parts | Peels | |
| Other cancers | Breast cancer, Colorectal cancer, Lung cancer | |
| Target gene or protein | Caspase 3,Caspase 8, Caspase 9, Bax, Bid, tBid, p53, p21/cip1, Fas, FasL, PIK3CA, MMP9, PTGS2, IKK, PCNA | |
| Gene or Protein evidence | Western blotting showed that the protein levels of pro-apoptotic proteins including cleaved caspase-3, cleaved caspase-8, cleaved caspase-9, Bax, Bid, tBid, p53, p21/cip1, Fas and FasL were significantly upregulated by tangeretin. The results of molecular docking analyses revealed the advantage of tangeretin as an inhibitor of PIK3CA, MMP9, PTGS2, and IKK. Furthermore, tangeretin down-regulated PCNA expression on breast cancer-bearing rats. | |
| Target pathways | Stat3 signaling pathway, PI3K/Akt signaling pathway | |
| IC50 | 9 µM against MDA-MB-231 | |
| Potency | Our results in this study show that tangeretin inhibits the Stat3 signaling pathway and induces CSC death, indicating that tangeretin may be a potential natural compound that targets breast cancer cells and CSCs. | |
| Cell line/ mice model | MDA-MB-435, MCF-7, HT-29, MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | 68077 | |
| Additional PMIDs | 32503228 33326843 11056327 15757658 17197076 31646804 34335799 24938898 25418056 28276668 24573532 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:890757-1 | |
| Safety | acute toxic in puchem database |