| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-877 | |
| Phytochemical name or plant extracts | Tamarix articulata extract | |
| PMID | 32994715 | |
| Literature evidence | Such plants may contain novel compounds to display promising biological activities. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Tamarix articulata | |
| Geographical availability | Afghanistan, Algeria, Chad, Djibouti, Egypt, Eritrea, Ethiopia, Gulf States, India, Iran, Iraq, Kenya, Kuwait, Libya, Mauritania, Morocco, Niger, Oman, Pakistan, Palestine, Saudi Arabia, Senegal, Sinai, Socotra, Somalia, Sudan, Tunisia, Yemen | |
| Plant parts | Leaves, Stem, and Root | |
| Other cancers | Breast cancer, Colorectal cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | Our results demonstrate that all methanolic extracts of T. articulata showed antioxidant activity, however, the methanolic extract of dry leaves exhibits promising antioxidant effect with IC₅₀ value 49.08 ± 1.98, which was strongly supported by total phenolic (409.92 ± 6.03 mg GAE/g DW) and flavonoid (177.71 mg QE/g DW) content. Furthermore, MTT assay revealed that all methanolic extracts exhibit antiproliferative activity in MCF-7 (breast cancer) and RKO (colorectal cancer) cells with IC₅₀ values ranges from 219 ± 5.112 µg/ml to 253 ± 5.231 µg/ml and 220 ± 4.330 µg/ml to 325 ± 6.213 µg/ml, respectively. However, the most promising antiproliferative effect was displayed by methanolic extract of dry leaves with IC₅₀ values 219 ± 5.112 µg/ml and 220 ± 4.330 µg/ml, respectively. | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, RKO | |
| Additional information | The current study demonstrates that T. articulata methanolic extract exhibits promising anticancer potential to kill tumour cells by programmed cell death type I and II mechanisms and could be explored for potential drug candidate molecules to curtail cancer in the future. | |
| PubChem ID | NA | |
| Additional PMIDs | 34316277 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:828051-1 | |
| Safety | NA |