| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-38 | |
| Phytochemical name or plant extracts | Taheebo | |
| PMID | 19578798 | |
| Literature evidence | Herbal medicines may provide an alternative or complementary approach. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Tabebuia avellandae | |
| Geographical availability | Argentina Northwest, Bolivia, Brazil North, Brazil Northeast, Brazil Southeast, Brazil West-Central, Colombia, Costa Rica, El Salvador, French Guiana, Guatemala, Honduras, Mexico Central, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá, Paraguay, Peru, Suriname, Venezuela | |
| Plant parts | Bark | |
| Other cancers | Breast cancer | |
| Target gene or protein | Cyclin B1, PCNA, OKL38, Caspases, ESR1, CYP 1A1, CYP 1B1, Bcl-2 family, GADD-45 family | |
| Gene or Protein evidence | Taheebo modulated the gene expression of G2 specific cyclin B1 (-2.0-fold), S phase specific PCNA (-2.0-fold) and OKL38 (+11.0-fold), apoptosis specific GADD-45 family (+1.9-5.4-fold), Caspases (+1.6-1.7-fold), BCL-2 family (-1.5-2.5-fold), estrogen responsive ESR1 (-1.5-fold), and xeno-biotic metabolism specific CYP 1A1 (+19.8 fold) and CYP 1B1 (+7.9-fold). | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | A 6-h treatment with 1.5 mg/ml Taheebo modulated the gene expression of G2 specific cyclin B1 (-2.0-fold), S phase specific PCNA (-2.0-fold) and OKL38 (+11.0-fold), apoptosis specific GADD-45 family (+1.9-5.4-fold), Caspases (+1.6-1.7-fold), BCL-2 family (-1.5-2.5-fold), estrogen responsive ESR1 (-1.5-fold), and xeno-biotic metabolism specific CYP 1A1 (+19.8 fold) and CYP 1B1 (+7.9-fold). | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Taheebo, extracted from the inner bark of the Tabebuia avellandae tree found in the Brazilian Amazon, exhibits selective anti-proliferative effects in carcinoma cell lines. The anti-proliferative effects of Taheebo correlate with down-regulated cell cycle regulatory and estrogen responsive genes, and up-regulated apoptosis specific and xeno-biotic metabolism specific genes. | |
| PubChem ID | NA | |
| Additional PMIDs | 31632670 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:110853-1 | |
| Safety | NA |