| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1097 | |
| Phytochemical name or plant extracts | Syringin | |
| PMID | 31029906 | |
| Literature evidence | PURPOSE: In this study, we evaluated the anticancer potential of Syr on breast carcinoma and the mechanism involved. | |
| IUPAC name | (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-[(E)-3-hydroxyprop-1-enyl]-2,6-dimethoxyphenoxy]oxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Phenylpropanoid glycoside | |
| Source of phytochemicals or plant Extracts | Eleutherococcus senticosus | |
| Geographical availability | Amur, China North-Central, China South-Central, Inner Mongolia, Japan, Khabarovsk, Korea, Manchuria, Primorye, Sakhalin | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | PARP, XIAP, MAP2K1, PIK3CA, HRAS, EGFR, Caspase3, and PTGS2 | |
| Gene or Protein evidence | we found that colony formation inhibition, cell cycle arrest in the G2/M phase, down-regulation of X-linked inhibitor of apoptosis protein (XIAP), cleaved poly (ADP-ribose) polymerase (PARP) and caspase-3/9 activation were observed in MCF7 and MDA-MB-231 cells treated with Syr. Bioinformatics results showed that MAP2K1, PIK3CA, HRAS, EGFR, Caspase3, and PTGS2 were the hub targets of Syringin against BC. And PIK3CA and HRAS were related to the survival and prognosis of BC patients, the PIK3CA-hsa-mir-139-5p-LINC01278 and PIK3CA-hsa-mir-375 pathways might be closely related to the mechanism of Syringin against BC. | |
| Target pathways | Caspase-mediated apoptosis pathway, PI3K-AKT-PTGS2 and EGFR-RAS-RAF-MEK-ERK pathways | |
| IC50 | NA | |
| Potency | Our findings suggest that Syr induces oxidative stress to suppress the proliferation of breast cancer and thus might be an effective therapeutic agent to treat breast cancer. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | Syringin possessed the potent anti-osteoporosis activity on ovariectomized mice, and the underlying molecular mechanism may be related to the NF-κB and PI3K/AKT signaling pathways. | |
| PubChem ID | 5316860 | |
| Additional PMIDs | 31239861 25588942 31029906 33802543 35794555 29655696 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:90431-1 | |
| Safety | NA |