| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1792 | |
| Phytochemical name or plant extracts | Sulfuretin | |
| PMID | 23292685 | |
| Literature evidence | Therefore, inhibiting MMP-9 expression by sulfuretin may have therapeutic potential for controlling breast cancer invasiveness. | |
| IUPAC name | (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-6-hydroxy-1-benzofuran-3-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Calanticaria bicolor | |
| Geographical availability | Mexico Gulf, Mexico Northeast | |
| Plant parts | Heartwood | |
| Other cancers | Breast cancer | |
| Target gene or protein | MMP9 | |
| Gene or Protein evidence | Therefore, inhibiting MMP-9 expression by sulfuretin may have therapeutic potential for controlling breast cancer invasiveness. | |
| Target pathways | We demonstrated that sulfuretin mediated the inhibition of TPA-induced MMP-9 expression and that cell invasion in MCF-7 cells involved suppression of the NF-κB pathway. | |
| IC50 | NA | |
| Potency | Therefore, inhibiting MMP-9 expression by sulfuretin may have therapeutic potential for controlling breast cancer invasiveness. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | In conclusion, our results demonstrated that sulfuretin is a potent inhibitor of TPA-induced MMP-9 expression, and that it strongly blocked the NF-κB signaling pathway in breast carcinoma cells. | |
| PubChem ID | 5281295 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1060193-2 | |
| Safety | NA |