| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-764 | |
| Phytochemical name or plant extracts | Styrylpyrone derivative | |
| PMID | 12787481 | |
| Literature evidence | Author information: (1)School of Biosciences & Biotechnology, Faculty of Science & Technology, National University of Malaysia, 43600 Bangi, Selangor, Malaysia. alvinlee@email.com In the fight against cancer, novel chemotherapeutic agents are constantly being sought to complement existing drugs. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Goniothalamus tamirensis | |
| Geographical availability | Cambodia, Laos, Thailand, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax | |
| Gene or Protein evidence | Western blotting and immunostaining revealed up-regulation of the proapoptotic Bax protein expression. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | These results, therefore, suggest SPD as a potent cytotoxic agent on MCF-7 cells by inducing apoptosis through the modulation of Bax levels. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | SPD, however, did not affect the expression of the anti-apoptotic protein, Bcl-2. | |
| PubChem ID | NA | |
| Additional PMIDs | 14580263 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:73260-1 | |
| Safety | NA |