| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1605 | |
| Phytochemical name or plant extracts | Strobilanthes crispus extract | |
| PMID | 33511882 | |
| Literature evidence | Taken together, our results showed SH extract of S. crispus exhibiting their anti-proliferative activities by modulating apoptosis and cell cycle, but the underlying mechanisms exerted by LW extract requires further investigation. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract, Hexane extract | |
| Source of phytochemicals or plant Extracts | Strobilanthes crispus | |
| Geographical availability | Jawa, Lesser Sunda Is. | |
| Plant parts | Leaves and stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, Cyclin A2, Bax, Caspase 9 | |
| Gene or Protein evidence | Results showed that SH extract induces apoptosis by suppressing the protein expression of BCL-2 while the expression of pro-apoptotic proteins such as BAX and caspase nine were unchanged. Decrease of cyclin A2 in SH-treated cells suggested this effect was associated with the dysregulation of cell cycle. | |
| Target pathways | NA | |
| IC50 | Leaf water (LW) - 45 μg/mL against MDA-MB-231 Stem hexane (SH) extract - 60 μg/mL against MDA-MB-231 | |
| Potency | Taken together, our results showed SH extract of S. crispus exhibiting their anti-proliferative activities by modulating apoptosis and cell cycle, but the underlying mechanisms exerted by LW extract requires further investigation. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | However, LW extract showed no effects on apoptosis and cell cycle arrest in the treated cells. | |
| PubChem ID | NA | |
| Additional PMIDs | 25034326 30599223 22471785 26745050 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:55623-1 | |
| Safety | NA |