| Properties | Information |
|---|---|
| PhytoCAT-ID | PhytoCAT-1773 |
| Phytochemical name or plant extracts | Strigolactones |
| PMID | 22476848 |
| Literature evidence | Immunoblot analysis revealed that SLs analogs induce activation of the stress response mediated by both P38 and JNK1/2 MAPK modules and inhibits PI3K/AKT activation. |
| IUPAC name | NA |
| Phytochemicals’ class or type of plant extracts | Plant hormone |
| Source of phytochemicals or plant Extracts | NA |
| Geographical availability | NA |
| Plant parts | Root |
| Other cancers | Breast cancer, Prostate cancer |
| Target gene or protein | ATM, ATR, DNA-PKcs, PARP-1, RAD51 |
| Gene or Protein evidence | Here we report for the first time that SLs induce DNA damage in the form of DNA double-strand breaks (DSBs) and activate the DNA damage response signaling by inducing phosphorylation of ATM, ATR and DNA-PKcs, The tumor cells exhibited significantly higher sensitivity to the two most potent SL analogues with increased apoptosis confirmed by PARP1 cleavage compared to their normal counterpart cells, In response to SLs, RAD51, the homologous DSB repair protein, is ubiquitinated and targeted for proteasomal degradation and it fails to co-localize with γH2AX foci. |
| Target pathways | PI3K/AKT pathway |
| IC50 | NA |
| Potency | Immunoblot analysis revealed that SLs analogs induce activation of the stress response mediated by both P38 and JNK1/2 MAPK modules and inhibits PI3K/AKT activation. Taken together this study indicates that SLs may be promising anticancer agents whose activities may be achieved through modulation of stress and survival signaling pathways. |
| Cell line/ mice model | NA |
| Additional information | Strigolactones are a novel class of plant hormones produced in roots that regulate shoot and root development. |
| PubChem ID | 405237444 |
| Additional PMIDs | 22476848 24742967 26910887 |
| Additional sources of information | NA |
| Safety | NA |