| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1945 | |
| Phytochemical name or plant extracts | Stigmasterol | |
| PMID | 30591773 | |
| Literature evidence | The GC analysis of the most active extract (hexane) showed the presence of several potent phytochemicals such as stigmasterol, beta-Sitosterol, squalene, lupeol, octadecadienoic acid, and oleic acid. | |
| IUPAC name | (3S,8S,9S,10R,13R,14S,17R)-17-[(E,2R,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | |
| Phytochemicals’ class or type of plant extracts | Phytosterol | |
| Source of phytochemicals or plant Extracts | Citrus hystrix Garcinia penangiana Decaschistia parviflora | |
| Geographical availability | Citrus hystrix - Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, Lesser Sunda Is., Malaya, Maluku, Myanmar, New Guinea, Nicobar Is., Philippines, Solomon Is., Sulawesi, Sumatera, Thailand, Vanuatu, Vietnam, Wallis-Futuna Is. Garcinia penangiana - Borneo, Malaya, Sumatera Decaschistia parviflora - Cambodia, Laos, Myanmar, Thailand, Vietnam | |
| Plant parts | Fruits Leaves Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Oxidation products of stigmasterol interfere with the action of the female sex hormone 17beta-estradiol in cultured human breast and endometrium cell lines. | |
| Cell line/ mice model | HT29, MCF-7, PC3, U-87 MG | |
| Additional information | Cytotoxic effects against MCF-7 cells. The hexane extract inhibited the brain cell line (U-87 MG) with an IC50 of 50 μg/ml and significantly promoted cell apoptosis through the mitochondrial pathway and DNA fragmentation p < 0.001. | |
| PubChem ID | 5280794 | |
| Additional PMIDs | 32708115 19833183 19815390 24397958 32168546 32650455 32932909 33401558 17579897 35126602 23678813 26246431 24813683 24689209 28725148 30870993 30848216 21470575 34440504 33822305 26704644 26246833 27348403 33094642 17602714 22633846 27431771 23941898 12946404 19471192 32278024 18274278 23762112 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:771927-1 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:428167-1 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:559484-1 | |
| Safety | NA |