| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2156 | |
| Phytochemical name or plant extracts | Stevioside | |
| PMID | 31762632 | |
| Literature evidence | This shows purified stevioside is capable of inducing apoptosis indicating its promising anticancer activity. | |
| IUPAC name | [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,4S,5R,9S,10R,13S)-13-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylate | |
| Phytochemicals’ class or type of plant extracts | Diterpene glycoside | |
| Source of phytochemicals or plant Extracts | Stevia rebaudiana | |
| Geographical availability | Brazil Southeast, Brazil West-Central, Paraguay | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2, Caspase 9 | |
| Gene or Protein evidence | Taken together, our data indicated that stevioside induces the ROS-mediated mitochondrial permeability transition and results in the increased expression of apoptotic proteins such as Bax, Bcl-2 and Caspase-9. | |
| Target pathways | NA | |
| IC50 | 55 µM μM against MDA-MB-231 66 μM against SKBR-3 | |
| Potency | The IC50 obtained after treatment with stevioside on cancer cells MDA-MB-231 and SKBR3 are 55 µM and 66 µM respectively. This shows purified stevioside is capable of inducing apoptosis indicating its promising anticancer activity. | |
| Cell line/ mice model | MDA-MB-231, SKBR-3, MCF-7 | |
| Additional information | However, so far chemosensitization effects of stevioside on breast cancer have not been fully explained by other studies. Hence, additionally, this study also evaluates the chemosensitization potential of stevioside in combination with 5-FU. | |
| PubChem ID | 442089 | |
| Additional PMIDs | 23061910 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:245468-2 | |
| Safety | NA |