| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1121 | |
| Phytochemical name or plant extracts | St. John's Wort extract (SJWE) | |
| PMID | 33080824 | |
| Literature evidence | Our results indicate that SJWE might have great potential as a new anticancer therapy for triple-negative breast cancer by inducing prodeath autophagy and apoptosis. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Hypericum perforatum | |
| Geographical availability | Afghanistan, Albania, Algeria, Altay, Austria, Azores, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Canary Is., Central European Rus, China North-Central, China South-Central, China Southeast, Corse, Cyprus, Czechoslovakia, Denmark, East Aegean Is., East European Russia, Finland, France, Germany, Great Britain, Greece, Hungary, Iran, Iraq, Ireland, Italy, Kazakhstan, Kirgizstan, Krasnoyarsk, Kriti, Krym, Lebanon-Syria, Madeira, Morocco, Netherlands, North Caucasus, Northwest European R, Norway, Pakistan, Palestine, Poland, Portugal, Qinghai, Romania, Sardegna, Saudi Arabia, Sicilia, South European Russi, Spain, Sudan, Sweden, Switzerland, Tadzhikistan, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Uzbekistan, West Himalaya, West Siberia, Xinjiang, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2 and Bcl-xL | |
| Gene or Protein evidence | Consistent with the in vitro study, antiapoptotic proteins, Bcl-2 and Bcl-xL, were lowered by SJWE treatment | |
| Target pathways | SJWE regulated proliferation and apoptosis in MCF-7 breast cancer cells by inhibiting the AMPK/mTOR and Bcl-2 family pathways. Moreover, SJWE-induced autophagy activation and apoptosis led to the suppression of proliferation through modulation of the PI3K/mTOR pathway in the TNBC line MDA-MB-231 cells. | |
| IC50 | NA | |
| Potency | Our results indicate that SJWE might have great potential as a new anticancer therapy for triple-negative breast cancer by inducing prodeath autophagy and apoptosis. | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | In numerous clinical double-blind trials against placebo and other antidepressants the whole extract of St.-John's wort, e.g. as in Jarsin coated tablets, has proved to be just as effective as the other antidepressants for mild and moderate depression, but not for severe depression. | |
| PubChem ID | NA | |
| Additional PMIDs | 11155493 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:433719-1 | |
| Safety | NA |