| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2170 | |
| Phytochemical name or plant extracts | Spinasterol | |
| PMID | 15886524 | |
| Literature evidence | The ethanol-extracted components (PE1, PE4) had significant antiproliferative effects on breast cancer cell lines, including MCF-7, ZR-75-1, MDA-MB-231, SK-BR-3, and Hs578T. | |
| IUPAC name | (3S,5S,9R,10S,13R,14R,17R)-17-[(E,2R,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | |
| Phytochemicals’ class or type of plant extracts | Steroid | |
| Source of phytochemicals or plant Extracts | Pueraria mirifica Pueraria lobata | |
| Geographical availability | Thailand Cambodia, Caroline Is., China North-Central, China South-Central, China Southeast, Hainan, Inner Mongolia, Japan, Jawa, Korea, Laos, Malaya, Maluku, Manchuria, Myanmar, Nansei-shoto, New Guinea, Northern Territory, Ogasawara-shoto, Philippines, Primorye, Solomon Is., Taiwan | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | ERα, ERβ | |
| Gene or Protein evidence | Finally, a transfection assay showed that this component had an estrogenic effect similar to 17beta - estradiol, which activates both estrogen receptor alpha (ERalpha) and ERbeta. | |
| Target pathways | NA | |
| IC50 | PE-D was 6 µM | |
| Potency | NA | |
| Cell line/ mice model | NA | |
| Additional information | The NMR and mass data suggest that the active component in Sub PE-D2 is spinasterol (stigmasta-7,22-dien-3beta-ol), an isomer of stigmasterol, which is one of the phytoestrogens present in Pueraria extract | |
| PubChem ID | 5281331 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:516707-1 | |
| Safety | NA |