| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-36 | |
| Phytochemical name or plant extracts | Sphagneticola trilobata extract | |
| PMID | 34345598 | |
| Literature evidence | This study aims to investigate the potential of bioactive secondary metabolites contained in Sphagneticola trilobata (L.) J.F Pruski leaves as novel plant-derived anticancer agent. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Sphagneticola trilobata | |
| Geographical availability | Belize, Bolivia, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Central American Pac, Colombia, Costa Rica, Ecuador, French Guiana, Guatemala, Guyana, Honduras, Mexico Gulf, Mexico Northwest, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá, Peru, Suriname, Trinidad-Tobago, Venezuela | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | Antioxidant activity - 124.34 μg/ml | |
| Potency | In vitro MTT assay showed that our extract successfully reached 96% mortality with LC50 = 189.287 μg/mL, where the selective index of 2.5 suggest its selectivity against MCF-7 breast cancer cell line. In conclusion, the data of biological activities suggest the potential development of methanolic extract from S. trilobata leaves as a phytomedicine for breast cancer treatment. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | The inhibition zone values against E. coli and S. thypi (at extract concentration of 100 mg/mL) were 34.33 and 36 mm, respectively. Previously, we have investigated the ethyl acetate extract from S. trilobata leaves yielding 78.80% apoptosis percentage against MCF-7 breast cancer cell. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1093589-2 | |
| Safety | Based on the cytotoxicity studies, the LC50 value for MCF-7 was lower (189. 287 μg/mL than the Vero cells 465.357 μg/mL). |