| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-517 | |
| Phytochemical name or plant extracts | Sophora interrupta extract (SEA) | |
| PMID | 24748754 | |
| Literature evidence | The antioxidant activity of the S.interrupta root ethylacetate (SEA) extract at 100 µg/ml is equal to that of ascorbic acid at 50 µg/ml. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethylacetate extract | |
| Source of phytochemicals or plant Extracts | Sophora interrupta | |
| Geographical availability | India | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Prostate cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 250 µg/ml against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, PC-3 | |
| Additional information | Kaempferol-3-O-b-D-glucopyranoside, a Secondary metabolite of S.interrupta form 6 hydrogen bond interactions with Arg 202, Gln 207, Gly 227, Gly 229, Thr 231 and Ala 232 human DEAD box RNA helicase, DDX3 protein and is equivalent to crystal structure of adenosine mono phosphate to DDX3. Overall, it suggests that the SEA extract has anticancer compounds, and it can be used to enhance death receptor mediated cancer cell death. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:518859-1 | |
| Safety | NA |