| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1712 | |
| Phytochemical name or plant extracts | Solanum chacoense extract | |
| PMID | 32372670 | |
| Literature evidence | The goal of this study was to evaluate the biochemical profile and the anti-tumor potential of methanolic extracts obtained from S. chacoense leaves and tubers against three breast cancer cell lines in comparison to healthy endothelial cells (HUVEC). | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Solanum chacoense | |
| Geographical availability | Argentina Northeast, Argentina Northwest, Bolivia, Brazil South, Brazil Southeast, Paraguay, Peru, Uruguay | |
| Plant parts | Leaves and tubers | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2, STAT-3, CCND1, NF-κB | |
| Gene or Protein evidence | The treatment with the extracts induced overexpression of the pro-apoptotic gene BAX¸ down-regulation of the anti-apoptotic gene BCL-2 and the pro-proliferation genes NFkB, CCND1, and STAT3. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Thus S. chacoense extracts proved to be rich in compounds with anticancer proprieties and are capable of inducing selective cytotoxicity on MCF7 cell line. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Solanum chacoense (wild potato) is intensively used in breeding, its biochemical profile and putative human health-related traits being transferred into potato cultivars aimed for consumption. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:238539-2 | |
| Safety | NA |