| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-201 | |
| Phytochemical name or plant extracts | Snakegourd root polysaccharide | |
| PMID | 23086645 | |
| Literature evidence | CONCLUSION: The polysaccharide of snakegourd root can induce the apoptosis of MCF-7 cells,which is associated with the activation of intracellular Caspase-3 and Caspase-8. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Polysaccharide | |
| Source of phytochemicals or plant Extracts | Trichosanthes cucumerina | |
| Geographical availability | Assam, Bangladesh, Cambodia, China South-Central, China Southeast, East Himalaya, India, Jawa, Laccadive Is., Lesser Sunda Is., Maldives, Myanmar, Nepal, Northern Territory, Pakistan, Philippines, Queensland, Sri Lanka, Sulawesi, Thailand, Vietnam, West Himalaya, Western Australia | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Caspase 8 | |
| Gene or Protein evidence | The characteristic ladder of apoptosis in DNA electrophoresis was detected in MCF-7 cells treated with 10.0 μmol/L polysaccharide of snakegourd root at d 2. The activities of Caspase-3 and Caspase-8 were increased in a time-dependent manner. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The maximal activities of intracellular Caspase-3 and Caspase-8 were (2.32 ±0.12)U/μg and (1.92 ±0.11)U/μg at d 2 and d 1, respectively when MCF-7 cells were treated with 10.0 μmol/L. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | The polysaccharide of snakegourd root can induce the apoptosis of MCF-7 cells,which is associated with the activation of intracellular Caspase-3 and Caspase-8. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:294175-1 | |
| Safety | NA |