| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-556 | |
| Phytochemical name or plant extracts | Smilax spinosa extract | |
| PMID | 22752086 | |
| Literature evidence | Based on our data Smilax spinosa may be a promising source for novel anticancer agents. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Smilax spinosa Miller | |
| Geographical availability | Belize, Bolivia, Brazil Northeast, Colombia, Costa Rica, Ecuador, El Salvador, French Guiana, Guatemala, Guyana, Honduras, Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá, Peru, Southwest Caribbean, Suriname, Trinidad-Tobago, Venezuela | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer | |
| Target gene or protein | CYP1A1, p21, STAT-3, Caspase 9, Caspase 8, Caspase 3 | |
| Gene or Protein evidence | Furthermore, fractionation of this extract yielded fraction F2, which exhibited enforced pro-apoptotic activity, and activated CYP1A1. Proteins that are relevant for cell cycle progression and apoptosis, as well as proto-oncogenes were investigated by western blotting. This revealed that the methanol extract increased the levels of p21 and this may have caused cell cycle attenuation. The derivative fraction F2 induced apoptosis through the intrinsic pathway, which correlated with the inhibition of Stat3 phosphorylation and concomitant induction of caspase 9, then caspase 8 and caspase 3. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Based on our data Smilax spinosa may be a promising source for novel anticancer agents. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, HL60 | |
| Additional information | In summary, the methanol extract and the derivative fraction F2 of S. spinosa showed anti-neoplastic effects in HL-60 cells and CYP1A1 activation in estrogen receptor-positive MCF-7 breast cancer cells but not in estrogen-negative MDA-MB231 breast cancer cells. By using several solvents the methanol extract was by far the most potent against HL60 cell proliferation (50% inhibition at 60 µg/ml). | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:541862-1 | |
| Safety | NA |