| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-554 | |
| Phytochemical name or plant extracts | Smilax china extract | |
| PMID | 25333945 | |
| Literature evidence | Conventional and alternative drugs, including Chinese herbal remedies, have been developed to target metastatic cancer cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic Extract | |
| Source of phytochemicals or plant Extracts | Smilax china | |
| Geographical availability | Manchuria | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | TIMP1, TIMP2, uPA, uPAR | |
| Gene or Protein evidence | By contrast, SCLE significantly increased the mRNA levels of TIMP1 and TIMP2. SCLE markedly inhibited the proliferation and migration of MDA-MB-231 cells, and reduced the mRNA levels of the extracellular matrix (ECM) degradation-associated molecules uPA, uPAR. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | These findings show that SCLE exerts an anti-metastatic effect on human breast cancer cells, which may involve the modulation of ECM degradation. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | SCLE markedly inhibited the proliferation and migration of MDA-MB-231 cells, and reduced the mRNA levels of the extracellular matrix (ECM) degradation-associated molecules uPA, uPAR. | |
| PubChem ID | NA | |
| Additional PMIDs | 20669365 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:541353-1 | |
| Safety | NA |