| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1893 | |
| Phytochemical name or plant extracts | Sinopodophylline B | |
| PMID | 28411691 | |
| Literature evidence | Compounds 1-6, 9-11, and 14-17 were tested for their cytotoxicity against human breast-cancer T47D, MCF-7 and MDA-MB-231 cells in vitro, and compounds 2, 5, 6, 10 and 11 showed significant cytotoxicity (IC50 values < 10 μmol·L-1) against T47D cells. | |
| IUPAC name | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-methoxy-8-(4-methylpent-3-en-1-yl)-4H-chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Sinopodophyllum hexandrum | |
| Geographical availability | Afghanistan, China North-Central, China South-Central, East Himalaya, Nepal, Pakistan, Qinghai, Tibet, West Himalaya | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 1.5 ± 0.07 μmol/Lagainst T47D 44.2 ± 1.58 μmol/L against MDA-MB-231 | |
| Potency | compounds 2, 5, 6, 10 and 11 showed significant cytotoxicity (IC50 values < 10 μmol·L-1) against T47D cells. Compound 2 is Sinopodophylline B | |
| Cell line/ mice model | T47D, MCF-7, MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77137821-1 | |
| Safety | NA |