| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-185 | |
| Phytochemical name or plant extracts | Sinigrin | |
| PMID | 15231456 | |
| Literature evidence | DSS did not inhibit COX enzymes or lipid peroxidation at 250 microg/ml. | |
| IUPAC name | potassium,[(E)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]sulfanylbut-3-enylideneamino] sulfate | |
| Phytochemicals’ class or type of plant extracts | Glucosinolate | |
| Source of phytochemicals or plant Extracts | Armoracia rusticana | |
| Geographical availability | South European Russi, Ukraine | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Colon cancer, Lung cancer, Brain cancer | |
| Target gene or protein | COX-1 | |
| Gene or Protein evidence | The COX-1 enzyme inhibitory activity of sinigrin at 250 µg/ml was 20%, and no COX-2 enzyme inhibitory activity was observed. Sinigrin inhibited lipid peroxidation in the liposome model by 71% at 250 µg/ml. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Sinigrin showed no proliferating effect on the tumor cells tested. | |
| Cell line/ mice model | HCT-116, MCF-7, NCIH460, CNS, SF-268 | |
| Additional information | Sinigrin inhibited lipid peroxidation by 71% at 250 microg/ml. | |
| PubChem ID | 23682211 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:278747-1 | |
| Safety | NA |