| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-859 | |
| Phytochemical name or plant extracts | Simalikalactone D | |
| PMID | 31940804 | |
| Literature evidence | SKD showed high cytotoxicity activity, with an IC50 of 55, 58, and 65 nM in A2780CP20 (ovarian), MDA-MB-435 (breast), and MDA-MB-231 (breast) cell lines, respectively. | |
| IUPAC name | [(1R,2S,3R,6R,8S,12S,13S,14R,15R,16S,17R)-12,15,16-trihydroxy-9,13,17-trimethyl-4,11-dioxo-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-en-3-yl] (2R)-2-methylbutanoate | |
| Phytochemicals’ class or type of plant extracts | Quassinoid | |
| Source of phytochemicals or plant Extracts | Simarouba tulae | |
| Geographical availability | Puerto Rico | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Ovarian cancer, Prostate cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 58 nM against MDA-MB-435 65 nM against MDA-MB-231 | |
| Potency | Exposure to SKD led to 15% inhibition of the migration of MDA-MB-231 cells. | |
| Cell line/ mice model | MDA-MB-435, MDA-MB-231, A2780CP20, 4T1, MCF10A, PC3, HCT-116, SH-SY5Y | |
| Additional information | NA | |
| PubChem ID | 15161842 | |
| Additional PMIDs | 31940804 15165136 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:814136-1 | |
| Safety | NA |