| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1233 | |
| Phytochemical name or plant extracts | Siegesbeckia orientalis extract | |
| PMID | 25470271 | |
| Literature evidence | Overall, this study suggests that SOE is a promising anticancer agent for treating endometrial cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Siegesbeckia orientalis | |
| Geographical availability | Amur, Angola, Assam, Baltic States, Belarus, Borneo, Cambodia, Cameroon, Central European Rus, China North-Central, China South-Central, China Southeast, East European Russia, East Himalaya, Eritrea, Ethiopia, Hainan, India, Inner Mongolia, Iran, Japan, Jawa, Kazakhstan, Khabarovsk, Kirgizstan, Korea, Laos, Lesser Sunda Is., Madagascar, Malawi, Malaya, Maluku, Manchuria, Mauritius, Mozambique, Myanmar, Nansei-shoto, Nepal, New South Wales, North Caucasus, North European Russi, Northern Territory, Northwest European R, Pakistan, Philippines, Primorye, Queensland, Rodrigues, Réunion, Socotra, South European Russi, Sri Lanka, Sulawesi, Sumatera, Tadzhikistan, Taiwan, Thailand, Tibet, Transcaucasus, Turkey, Turkmenistan, Uzbekistan, Victoria, Vietnam, West Himalaya, Yemen, Yugoslavia, Zambia, Zimbabwe | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Lung cancer, Pharynx squamous cancer, Prostate cancer, Uterus cancer, Liver cancer | |
| Target gene or protein | Caspase 3, Caspase 8, Caspase 9, Bad, Bak, Bax, Bcl-2 | |
| Gene or Protein evidence | Caspase-3, -8, -9, Bad, Bak, Bax, Bcl-xL and Bcl-2 proteins in RL95-2 cells after treatment with 0–100 µg/mL SOE for 24 h were detected. | |
| Target pathways | NA | |
| IC50 | 124.3 ± 4.0 µg/mL against MDA-MB-231 | |
| Potency | Moreover, SOE was also effective against A549 (lung cancer), Hep G2 (hepatoma), FaDu (pharynx squamous cancer), MDA-MB-231 (breast cancer), and especially on LNCaP (prostate cancer) cell lines. | |
| Cell line/ mice model | MDA-MB-231, A549, Hep G2, FaDu , LNCaP | |
| Additional information | Overall, this study suggests that SOE is a promising anticancer agent for treating endometrial cancer. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:249084-1 | |
| Safety | NA |