| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-821 | |
| Phytochemical name or plant extracts | Sichuan pepper extracts | |
| PMID | 16418572 | |
| Literature evidence | So far FK228 is the most potent among the HDAC (histone deacetylase) inhibitors that block the activation of both PAK1 and another kinase AKT, downstream of PI-3 kinase. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Zanthoxylum piperitum | |
| Geographical availability | East Himalaya, Japan, Korea | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Cyclin D1, PAK1 | |
| Gene or Protein evidence | Here we provide the first evidence that extracts of Chinese/ Japanese peppercorns (Zanthoxyli Fructus) from the plant Zanthoxylum piperitum called "Hua Jiao"/"Sansho", block selectively the key kinase PAK1, leading to the downregulation of cyclin D1. | |
| Target pathways | PAK1/Cyclin D1 Pathway | |
| IC50 | 10 µg/ml against MDA-MB-231 | |
| Potency | The Chinese pepper extract selectively inhibits the growth of NF1-deficient malignant peripheral nerve sheath tumor (MPNST) cells, without affecting the growth of normal fibroblasts, and suppresses the growth of NF1-deficient human breast cancer (MDA-MB-231) xenograft in mice. | |
| Cell line/ mice model | MDA-MB-231 xenograft in mice | |
| Additional information | Our data suggest that these peppercorn extracts would be potentially useful for the treatment of PAK1-dependent NF such as MPNST, in addition to a variety of PAK1-dependent cancers including breast cancers. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:775951-1 | |
| Safety | NA |