| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2121 | |
| Phytochemical name or plant extracts | Shisanbilactone A | |
| PMID | 34029653 | |
| Literature evidence | In an evaluation of antiproliferative activities against human cancer cell lines, some triterpenes exhibited significant activities against human breast carcinoma MCF-7 cells as compared to the other cell lines (A549, HeLa, and RPMI8226). | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Triterpene | |
| Source of phytochemicals or plant Extracts | Schisandra chinensis | |
| Geographical availability | Amur, China North-Central, Inner Mongolia, Japan, Khabarovsk, Korea, Manchuria, Primorye, Sakhalin | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Lung cancer, Cervical cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 9.3 μM against MCF-7 | |
| Potency | Among tested triterpenes, 3, 4, 8, 9, and 13, possessing the α,β-unsaturalted δ-lactone moiety, exhibited significant antiproliferative activities against MCF-7 cells, which were comparable with those of positive controls. Compound 8 is Shisanbilactone A | |
| Cell line/ mice model | MCF-7, A549, HeLa, RPMI8226 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60456331-2 | |
| Safety | NA |