| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-118 | |
| Phytochemical name or plant extracts | Shionone | |
| PMID | 33099919 | |
| Literature evidence | Studies are focusing to develop novel systemic therapies for the treatment of this disease. | |
| IUPAC name | (1R,4aS,4bS,6aS,8R,10aR,10bS,12aS)-1,4b,6a,8,10a,12a-hexamethyl-8-(4-methylpent-3-enyl)-1,3,4,4a,5,6,7,9,10,10b,11,12-dodecahydrochrysen-2-one | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Aster poliothamnus | |
| Geographical availability | China North-Central, China South-Central, Qinghai, Tibet | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Caspase 9, Bcl-2, Bax | |
| Gene or Protein evidence | Shionone caused cleavage of caspase-3 and 9. The expression of Bax was increased and that of Bcl-2 was decreased upon Shionone treatment. | |
| Target pathways | Ras/Raf/MEK/ERK and STAT3 signaling pathways | |
| IC50 | 14 µM against SKBR-3 | |
| Potency | Taken all together, the study established the anticancer role of triterpenoid Shionone in restricting the growth and proliferation of human breast cancer cells. | |
| Cell line/ mice model | SKBR-3, MB-157 | |
| Additional information | The results showed that in vitro administration of Shionone led to decline of proliferation of breast cancer cells. The reduction of proliferative rates was attributed to the induction of apoptosis of breast cancer cells. | |
| PubChem ID | 12315507 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:182025-1 | |
| Safety | NA |