| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-192 | |
| Phytochemical name or plant extracts | Semialarium mexicanum extract | |
| PMID | 30425433 | |
| Literature evidence | These results suggest that S. mexicanum root bark has a potential application in breast cancer treatment. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Semialarium mexicanum | |
| Geographical availability | Belize, Costa Rica, El Salvador, Guatemala, Honduras, Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá, Venezuela | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | The petroleum ether extract of S. mexicanum root bark induced cell death by apoptosis in MDA-MB-231, MCF7, and MCF 10A cells. This cell death was associated with decreased metabolic activity and the generation of ROS. | |
| IC50 | 55.5 μg/mL against MDA-MB-231 75.8μg/mL against MCF7 | |
| Potency | These results suggest that S. mexicanum root bark has a potential application in breast cancer treatment. | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:284864-2 | |
| Safety | NA |