| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1187 | |
| Phytochemical name or plant extracts | Semecarpus anacardium nut extract (SA) | |
| PMID | 17572113 | |
| Literature evidence | SA was discovered to induce rapid Ca(2+) mobilization from intracellular stores of T47D cell line, and its cytotoxicity against T47D was well correlated with altered mitochondrial transmembrane potential. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Semecarpus anacardium | |
| Geographical availability | Assam, Bangladesh, East Himalaya, India, Myanmar, Nepal, West Himalaya | |
| Plant parts | Nut | |
| Other cancers | Breast cancer | |
| Target gene or protein | HIF-1, Bcl-2, Bax, cyt-c, Caspase 3, Caspase 9, PARP | |
| Gene or Protein evidence | The mechanism of this inhibition seems to be through an action of SA on expression of HIF-1 and its downstream targets. At the molecular level, these changes are accompanied by decrease in bcl(2) and increase in bax, cytochrome c, caspases and PARP cleavage, and ultimately by internucleosomal DNA fragmentation. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Our study demonstrates that SA treatment inhibit the formation of microvessels, as well as the activity of glycolytic enzymes in mammary carcinoma, suggesting SA may inhibit the growth of tumors by depriving the energy and further malignant progression through antiangiogenic ability. | |
| Cell line/ mice model | T47D, Cancer rats | |
| Additional information | The nut of S. anacardium is reported useful for a variety of ailments such as insanity, fever, asthma, dysentery, neurological disorders, cardiac troubles, enlargement of spleen, alopecia, ulcers, corns, leprosy, leucoderma, piles, rheumatism and cancer. | |
| PubChem ID | NA | |
| Additional PMIDs | 17280655 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:71196-1 | |
| Safety | NA |