| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-762 | |
| Phytochemical name or plant extracts | Selenium (Se)-containing polysaccharides | |
| PMID | 27865619 | |
| Literature evidence | It is concluded that Se-containing polysaccharides from P. fortuneana potently inhibit the growth and induce apoptosis of TNBC cells and can be potential anticancer agent for TNBC. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Polysaccharide | |
| Source of phytochemicals or plant Extracts | Pyracantha fortuneana | |
| Geographical availability | Assam, China North-Central, China South-Central, China Southeast, East Himalaya, India, Myanmar, Nepal, Pakistan, Tibet, Vietnam, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, Bax, PUMA, Noxa, Bcl-2, Bax, Caspase 3, Caspase 9, p53 | |
| Gene or Protein evidence | In vitro studies showed that treatment of triple negative breast cancer (TNBC) MDA-MB-231 cells with Se-PFPs (1) inhibited cell growth dose-dependently by arresting cells at G2 phase via inhibiting CDC25C-CyclinB1/CDC2 pathway, (2) caused apoptosis associated with increased p53, Bax, Puma and Noxa, decreased Bcl2, increased Bax/Bcl2 ratio and increased activities of caspases 3/9, suggesting its effect on p53-mediated cytochrome c-caspase pathway | |
| Target pathways | p53-mediated cytochrome c-caspase pathway CDC25C-CyclinB1/CDC2 pathway | |
| IC50 | NA | |
| Potency | It is concluded that Se-containing polysaccharides from P. fortuneana potently inhibit the growth and induce apoptosis of TNBC cells and can be potential anticancer agent for TNBC. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | This extract contained 93.7% (w/w) of carbohydrate, 2.1% (w/w) of uronic acid and 3.7μg/g of Se, and was considered as Se-conjugated polysaccharides (Se-PFPs). | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:730613-1 | |
| Safety | Treatment of nude mice bearing MDA-MB-231-derived xenograft tumors with Se-PFPs significantly reduced tumor growth without altering body weight, confirming its antitumor activity without toxic side effects. |