| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2165 | |
| Phytochemical name or plant extracts | Scutellariae radix | |
| PMID | 26852865 | |
| Literature evidence | Cell line studies indicated that SR activated the BCRP-mediated efflux transport, whereas the serum metabolites of SR inhibited both the BCRP- and MRP2-mediated efflux transports. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Roots of Scutellaria baicalensis Georgi | |
| Source of phytochemicals or plant Extracts | Scutellaria baicalensis | |
| Geographical availability | Amur, Buryatiya, China North-Central, China South-Central, Chita, Inner Mongolia, Irkutsk, Khabarovsk, Korea, Manchuria, Mongolia, Primorye, Vietnam, Yakutskiya | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | BCRP, MRP2 | |
| Gene or Protein evidence | Cell line studies indicated that SR activated the BCRP-mediated efflux transport, whereas the serum metabolites of SR inhibited both the BCRP- and MRP2-mediated efflux transports. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | In conclusion, SR ingestion increased the systemic exposure and MRT of MTX via modulation on MRP2 and BCRP. | |
| Cell line/ mice model | Rats | |
| Additional information | The results showed that 1.0 g/kg of SR significantly increased Cmax, AUC(0-30), AUC(0-2880), and mean residence time (MRT) of MTX by 50%, 45%, 501%, and 347%, respectively, and 2.0 g/kg of SR significantly enhanced the AUC(0-2880) and MRT by 242% and 293%, respectively, but decreased AUC(0-30) by 41%. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:458155-1 | |
| Safety | NA |