| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1182 | |
| Phytochemical name or plant extracts | Scutellarein | |
| PMID | 29097115 | |
| Literature evidence | The present study aimed to characterize the metabolism and further antiproliferative activity of the hydroxylated flavonoids apigenin, luteolin, scutellarein, kaempferol and quercetin in CYP1 recombinant enzymes and in the CYP1 expressing cell lines MCF7 and MDA-MB-468, respectively. | |
| IUPAC name | 5,6,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Erigeron breviscapus | |
| Geographical availability | China South-Central, China Southeast, Tibet | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | CYP1A1, CYP1B1 | |
| Gene or Protein evidence | The present study aimed to characterize the metabolism and further antiproliferative activity of the hydroxylated flavonoids apigenin, luteolin, scutellarein, kaempferol and quercetin in CYP1 recombinant enzymes and in the CYP1 expressing cell lines MCF7 and MDA-MB-468, respectively. Taken collectively, the data demonstrate that the metabolism of hydroxylated flavonoids by cytochrome P450 CYP1 enzymes, notably CYP1A1 and CYP1B1, can enhance their antiproliferative activity in breast cancer cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Taken collectively, the data demonstrate that the metabolism of hydroxylated flavonoids by cytochrome P450 CYP1 enzymes, notably CYP1A1 and CYP1B1, can enhance their antiproliferative activity in breast cancer cells. | |
| Cell line/ mice model | MDA-MB-468, MCF-7, MCF10A | |
| Additional information | Scutellarein was suggested as a renal protective agent against ischemia-induced damage in AKI. The protective properties of scutellarein may be through inhibition of COX-2. | |
| PubChem ID | 5281697 | |
| Additional PMIDs | 27835979 35215292 29389889 19666078 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:203633-1 | |
| Safety | NA |