| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1354 | |
| Phytochemical name or plant extracts | Scrophularia oxysepala extract | |
| PMID | 25725141 | |
| Literature evidence | Dichloromethane fractions of Scrophularia oxysepala extract induce apoptosis in MCF-7 human breast cancer cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Dichloromethane extract | |
| Source of phytochemicals or plant Extracts | Scrophularia oxysepala | |
| Geographical availability | Iran | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Caspase 9 mRNA, Bcl-2 gene, NF-?B gene | |
| Gene or Protein evidence | The fractions have resulted in an increased expression of Caspase-3 and Caspase-9 mRNA. In malignant cells, a lower rate of increase in Bcl-2 gene expression was evident 24 hours after exposure to the fractions. They concluded that growth inhibition and cell death was due to the activation of Caspase-3 and down-regulation of cell cycle regulators, proto-oncogenes and NF-kappaB gene expression. | |
| Target pathways | NA | |
| IC50 | 75 µg/ml against MCF-7 | |
| Potency | The present study demonstrates that, dichloromethane fractions of Scrophularia oxysepala induce apoptosis in MCF-7 breast cancer cells in a dose-dependent manner via mitochondrial intrinsic pathway. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:809411-1 | |
| Safety | NA |