| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2082 | |
| Phytochemical name or plant extracts | Scrophularia frigida Boiss extract | |
| PMID | 27755942 | |
| Literature evidence | Some species of the Scrophularia genus have been extensively used as a natural remedy for treatment of various medical conditions. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Scrophularia frigida Boiss | |
| Geographical availability | Iran, Turkmenistan | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Human epidermal growth factor receptor 2, myeloid cell Leukemia-1, Caspase 3, Caspase 9 | |
| Gene or Protein evidence | It is suggested that the extracts exert their anti-proliferative effect through multiple implications such as suppressing growth, arresting the cell cycle, increased DNA fragmentation, downregulation of the expression of human epidermal growth factor receptor 2 and myeloid cell Leukemia-1, and upregulation of pro-apoptotic messenger RNAs like caspase-3 and caspase-9. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Extracts of Scrophularia frigida Boiss display potent antitumor effects in human breast cancer cells by inducing apoptosis and inhibition of expression of the human epidermal growth factor receptor 2 | |
| Cell line/ mice model | NA | |
| Additional information | Taken together, the results obtained indicate that S. frigida Boiss extracts may contain effective compounds that can be used as a therapeutic anticancer agent. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:809198-1 | |
| Safety | NA |