| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-848 | |
| Phytochemical name or plant extracts | Scrophularia atropatana extract | |
| PMID | 30256066 | |
| Literature evidence | The present study was done to reveal the effects of Scrophularia atropatana extract on epigenetic situation of TP53 gene promoter and the expression levels of anti-apoptotic gene, survivin and its potential for production of cancer epi-drugs. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Dichloromethane extract | |
| Source of phytochemicals or plant Extracts | Scrophularia atropatana | |
| Geographical availability | Iran, Transcaucasus, Turkey | |
| Plant parts | Leaves and stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | Tp53, Survivin | |
| Gene or Protein evidence | MSP on TP53 promoter with methylated and unmethylated primers showed that, the extract had considerable effects on the methylation status of this gene. Moreover, a noticeable effect on the survivin gene expression was observed, where exposure to the extract was led to a significant decrease in mRNA expression. | |
| Target pathways | Cleavage PARP protein, decrease in the mRNA expression levels of bcl-2 and increase expression of Caspase-3 and Caspase-9 mRNA, highlights that the induction of apoptosis was the main mechanism of cell death. Moreover the expression study of Caspase-9 mRNA showed that, the extracts have induced apoptosis via intrinsic mitochondrial pathway. | |
| IC50 | 223 µg/ml against MCF-7 | |
| Potency | Accordingly, SADCM could be considered as a potential source for production of cancer epi-drugs. | |
| Cell line/ mice model | MCF-7, L929 | |
| Additional information | The treatment of MCF-7 cells with dichloromethanolic and methanolic extracts of S. atropatana resulted in morphological changes, cytotoxic and apoptotic effect on this tumor cells while there was no significant inhibitory effect on normal cells. | |
| PubChem ID | NA | |
| Additional PMIDs | 29071220 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:809037-1 | |
| Safety | NA |