| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-411 | |
| Phytochemical name or plant extracts | Sclareol | |
| PMID | 29562495 | |
| Literature evidence | In conclusion, Sclareol can inhibit the proliferation of MG63 cells, and induce cell apoptosis and decrease mitochondrial membrane potential suggesting the inhibition of osteosarcoma cells by sclareol might be via both apoptosis induction and decreasing mitochondrial membrane potential. | |
| IUPAC name | (1R,2R,4aS,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Salvia sclarea | |
| Geographical availability | Afghanistan, Albania, Algeria, Bulgaria, Corse, Cyprus, France, Greece, Iran, Italy, Kazakhstan, Kirgizstan, Krym, Lebanon-Syria, North Caucasus, Palestine, Portugal, Romania, Sardegna, Sinai, Spain, Tadzhikistan, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Uzbekistan, West Himalaya, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | IL-4, IFN-γ | |
| Gene or Protein evidence | Furthermore, a significant decrease in the level of IL-4 and an increase in the level of IFN-γ were noticed in the intraperitoneally injected Sclareol group (p<0.05). | |
| Target pathways | NA | |
| IC50 | 32.65 ± 1.15 μg/ml against MCF-7 | |
| Potency | By all means, the findings confirmed that the activity of Sclareol could reduce the tumor growth in vivo against breast cancer. | |
| Cell line/ mice model | MCF-7, breast-cancer-bearing Balb/c mice, HeLa | |
| Additional information | Our results suggest that Sclareol, by reducing Treg cells frequency and also tumor size can enhance the effect of cancer therapy as an immuno-stimulant. | |
| PubChem ID | 163263 | |
| Additional PMIDs | 28278660 29562495 25236692 31089375 30946903 20409537 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:457210-1 | |
| Safety | NA |