| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-693 | |
| Phytochemical name or plant extracts | Saururus chinensis extract | |
| PMID | 21111586 | |
| Literature evidence | Moreover, we observed that SC potentiated paclitaxel-induced apoptosis in MCF-7 cells and sauchinone is a major active constituent of SC, which could induce apoptosis in the cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methylene chloride fraction from SC | |
| Source of phytochemicals or plant Extracts | Saururus chinensis | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Hainan, Japan, Korea, Nansei-shoto, Philippines, Qinghai, Taiwan, Vietnam | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Prostate cancer | |
| Target gene or protein | VEGF, Cyclin D1, Bcl-2, Caspase-3 | |
| Gene or Protein evidence | SC was shown to down-regulate various angiogenetic (VEGF), proliferative (Cyclin D₁, anti-apoptotic (Bcl-2) gene products in these cells. Taken together, our data provide the evidence that SC induces apoptosis depending on caspase-3 activation and overcomes the natural biological resistance to chemotherapy found in human prostate and breast cancer cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | SC exerted the most potent cytotoxicity in LNCaP and MCF-7 cells. | |
| Cell line/ mice model | LNCaP, MCF-7 | |
| Additional information | Taken together, our data provide the evidence that SC induces apoptosis depending on caspase-3 activation and overcomes the natural biological resistance to chemotherapy found in human prostate and breast cancer cells. | |
| PubChem ID | NA | |
| Additional PMIDs | 30505186 28278686 32033472 18841903 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:684080-1 | |
| Safety | NA |