| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1072 | |
| Phytochemical name or plant extracts | Sasanquasaponin (SQS) | |
| PMID | 23164604 | |
| Literature evidence | Recent studies have shown that SQS possesses potent anti-tumor activities in human leukemia Jurkat cells and human hepatoma HepG2 cells. | |
| IUPAC name | 10-[3-[4,5-dihydroxy-6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-(3,4,5-trihydroxyoxan-2-yl)oxyoxan-2-yl]oxy-2-hydroxy-4,5,9,9,13,20-hexamethyl-24-oxahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracosane-20-carbaldehyde | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Camellia oleifera | |
| Geographical availability | Assam, China South-Central, China Southeast, Hainan, Laos, Myanmar, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Liver cancer | |
| Target gene or protein | p21, Cyclin D1 | |
| Gene or Protein evidence | Stimulation of MCF-7 with SQS induced upregulation of p21 and downregulation of cyclin D1, which can cause G1 cell cycle arrest. | |
| Target pathways | Stimulation also induced activation of E2F1 and downregulation of p53, indicating that SQS induces cell cycle arrest and apoptosis via a p53-independent pathway, | |
| IC50 | NA | |
| Potency | Our results demonstrate the potential application of SQS as an anti-breast cancer agent. | |
| Cell line/ mice model | MCF-7, HepG2 | |
| Additional information | NA | |
| PubChem ID | 22715020 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:828535-1 | |
| Safety | NA |