| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1939 | |
| Phytochemical name or plant extracts | Santolina corsica extracts | |
| PMID | 30257409 | |
| Literature evidence | Antioxidant activity was determined by β-carotene bleaching, Ferric Reducing Activity Power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) tests. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | n-Hexane (EHS) extrac, Methanolic (EMS) extract | |
| Source of phytochemicals or plant Extracts | Santolina corsica Jord | |
| Geographical availability | Corse, Sardegna | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Cervical cancer, Prostate cancer, Lung cancer | |
| Target gene or protein | COX-2 | |
| Gene or Protein evidence | In addition, EHS treatment significantly decreased COX-2 expression levels with respect to those of the control (LPS-stimulated RAW 264.7 cells treated with DMSO) | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | S. corsica extracts might be potentially useful in cancer treatment, since reduce invasive and migratory potential of MDA-MB-231 cells triggering apoptosis. | |
| Cell line/ mice model | A549, HeLa, PC3, MCF-7, MDA-MB-231 | |
| Additional information | Santolina species showed various biological activities, including antibacterial, antifungal, antiviral, anti-inflammatory, cytotoxic, and hepatoprotective effects | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:241930-1 | |
| Safety | NA |