| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-765 | |
| Phytochemical name or plant extracts | Sanguiin H-6 | |
| PMID | 28835347 | |
| Literature evidence | These findings suggest that sanguiin H-6 is a potent therapeutic agent against breast cancer cells. | |
| IUPAC name | [(1R,2S,19R,20R,22R)-36-[5-[[(1R,2S,19R,20S,22R)-7,8,9,12,13,14,28,29,30,33,34,35-dodecahydroxy-4,17,25,38-tetraoxo-3,18,21,24,39-pentaoxaheptacyclo[20.17.0.02,19.05,10.011,16.026,31.032,37]nonatriaconta-5,7,9,11,13,15,26,28,30,32,34,36-dodecaen-20-yl]oxycarbonyl]-2,3-dihydroxyphenoxy]-7,8,9,12,13,14,28,29,30,33,34,35-dodecahydroxy-4,17,25,38-tetraoxo-3,18,21,24,39-pentaoxaheptacyclo[20.17.0.02,19.05,10.011,16.026,31.032,37]nonatriaconta-5,7,9,11,13,15,26,28,30,32(37),33,35-dodecaen-20-yl] 3,4,5-trihydroxybenzoate | |
| Phytochemicals’ class or type of plant extracts | Dimer of casuarictin | |
| Source of phytochemicals or plant Extracts | Rubus coreanus | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Korea, Xinjiang | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 8, Caspase 3, PARP, Bax, Bcl-2 | |
| Gene or Protein evidence | Furthermore, sanguiin H-6 induced the cleavage of caspase-8, caspase-3, and poly(ADP-ribose) polymerase, which resulted in apoptosis. However, cleavage of caspase-9 was only detectable in MCF-7 cells. In addition, sanguiin H-6 increased the ratio of Bax to Bcl-2 in both MCF-7 and MDA-MB-231 cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | These findings suggest that sanguiin H-6 is a potent therapeutic agent against breast cancer cells. In addition, it exerts its anticancer effect in an estrogen-receptor-independent manner. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | We found that sanguiin H-6 significantly reduced cell viability in a concentration-dependent manner. It also increased the rates at which MCF-7 and MDA-MB-231 cells underwent apoptosis. | |
| PubChem ID | 16130897 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:736034-1 | |
| Safety | NA |