| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-408 | |
| Phytochemical name or plant extracts | Salvianolic acid A | |
| PMID | 25442283 | |
| Literature evidence | These results not only provide insight into the potential application of SAA in reversing paclitaxel resistance, thus facilitating the sensitivity of breast cancer chemotherapy, but also highlight a potential role of transgelin 2 in the development of paclitaxel resistance in breast cancer. | |
| IUPAC name | (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]prop-2-enoyl]oxypropanoic acid | |
| Phytochemicals’ class or type of plant extracts | Stilbenoid | |
| Source of phytochemicals or plant Extracts | Salvia miltiorrhiza | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Transgelin 2, ABC transporter | |
| Gene or Protein evidence | Taken together, SAA can reverse paclitaxel resistance through suppressing transgelin 2 expression by mechanisms involving attenuation of PI3 K/Akt pathway activation and ABC transporter up-regulation. | |
| Target pathways | PI3 K/Akt pathway | |
| IC50 | NA | |
| Potency | The results demonstrated that SAA enhanced the sensitivity of MCF-7/PTX cells to paclitaxel by 2.9-, 5.0-, and 9.1- fold at concentrations of 3, 6, and 12 M, respectively. The RI value of 10 M verapamil was 10.2-fold. | |
| Cell line/ mice model | MCF-7/PTX | |
| Additional information | In addition, SAA effectively prevented transgelin 2 and adenosine-triphosphate binding cassette transporter (ABC transporter) including P-glycoprotein (P-gp), multidrug resistance associated protein 1 (MRP1), and breast cancer resistance protein (BCRP) up-regulation and exhibited inhibitory effect on PI3 K/Akt signaling pathway in MCF-7/PTX cells. | |
| PubChem ID | 5281793 | |
| Additional PMIDs | 25419632 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:456707-1 | |
| Safety | NA |