| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-407 | |
| Phytochemical name or plant extracts | Salvia miltiorrhiza extract | |
| PMID | 32963697 | |
| Literature evidence | The anticancer agent adriamycin (ADR) has long been recognized to induce a dose-limiting cardiotoxicity, while Salvia miltiorrhiza (SM) is a Chinese herb widely used for the treatment of cardiovascular disorders and its aqueous extract (SMAE) has shown anticancer as well as antioxidant effects. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Salvia miltiorrhiza | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Vietnam | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | Nrf2, HO-1 | |
| Gene or Protein evidence | We also noticed that there was a marked upregulation of detoxifying enzyme system in the presence of SMAE, and its exposure also contributed to an increase in Nrf2 and HO-1 content as well. | |
| Target pathways | ERK/p53/Bcl-xL/caspase-3 signaling pathway | |
| IC50 | NA | |
| Potency | Particularly, the simultaneous administration of ADR and SMAE could remarkably suppress the growth of breast cancer cells. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Collectively, these results support that ROS apoptosis-inducing molecule release is closely involved in ADR-induced cardiotoxicity while SMAE could prevent or mitigate the causative cardiomyopathy through controlling multiple targets without compromising the efficacy of chemotherapy. | |
| PubChem ID | NA | |
| Additional PMIDs | 15586243 20494511 34319041 22490436 19429433 21274285 25442283 24984021 26068969 31316608 32963697 34062127 21048307 32140267 30174047 25891082 25710938 26155286 30208247 22113823 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:456707-1 | |
| Safety | NA |