| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1808 | |
| Phytochemical name or plant extracts | Salvia dominica extract | |
| PMID | 24082637 | |
| Literature evidence | These could be considered as a potential source for novel anticancer therapy. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Salvia dominica | |
| Geographical availability | Cyprus, Lebanon-Syria, Palestine, Saudi Arabia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 5.83 ± 0.51 μg/ml against MCF-7 12.88 ± 0.64 μg/ml against T47D 68.33 ± 8.99 μg/ml against BT-474 14.03 ± 5.84 μg/ml against ZR-75-1 | |
| Potency | From the nice ethanol extracts under investigation, those of S. dominica and S. fruticosa showed an inhibitory concentration of 50% of cells (IC50) in concentrations less than 30μg/mL against the four cell lines under investigation. S. syriaca and S. hormium showed an IC50 below 30μg/ml for two out of the four cell lines. S. fruticosa, S. hormium and S. syriaca showed selectivity in their antiproliferative activity against estrogen receptor positive cell lines with minimal toxicity against normal human periodontal fibroblasts. | |
| Cell line/ mice model | MCF-7, T47D, ZR-75-1, BT-474 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:456131-1 | |
| Safety | NA |