| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-196 | |
| Phytochemical name or plant extracts | Salix safsaf extract | |
| PMID | 33008079 | |
| Literature evidence | In conclusion, our findings highlight the importance of natural phenolic and flavonoid compounds with unparalleled and unique antioxidant and anticancer properties. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Fractions F1–F3 were those extracted by petroleum ether (F1, 236 mg), Chloroform-CHCl3 (F2, 185 mg), and ethyle acetate-EtOAc (F3, 322 mg), sequentially. extract E1–E4 were those extracted by Ethanol (E1, 1.67 g), hydro-acetone (E2, 2.51 g), Aqueous infusion (E3, 3.03 g) and Aqueous decoction (E4, 3.75 g). | |
| Source of phytochemicals or plant Extracts | Salix safsaf | |
| Geographical availability | Algeria | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Cervical cancer, Colorectal cancer, Liver cancer | |
| Target gene or protein | Caspase 3, p53, Bcl-2, Bax | |
| Gene or Protein evidence | Results of immunoblotting and RT-qPCR assays showed that treatment with organic fractions under investigation resulted in significant up-regulation of pro-apoptotic protein and mRNA markers for Caspase-3, p53 and Bax, whereas it resulted in a significant reduction in amounts of both protein and mRNA of the anti-apoptotic marker Bcl-2. | |
| Target pathways | NA | |
| IC50 | F2 - 128.1 µg/mL against MCF-7 F3 - 111.72 µg/mL against MCF-7 for 72 h. | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, HCT-116, HeLa, HepG2 | |
| Additional information | FACS analysis also indicated that pre-treatment and co-treatment of human amniotic epithelial (WISH) cells exposed to the ROS H2O2 with EtOAc fraction provide a cytoprotective and antioxidant capacity against generated oxidative stress. In conclusion, our findings highlight the importance of natural phenolic and flavonoid compounds with unparalleled and unique antioxidant and anticancer properties. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:2920312-4 | |
| Safety | NA |